溶酶体水解酶与转运体的表征及年龄依赖性变化：对小分子和生物药药物代谢与转运的意义
Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs
作者：Darshak Chandulal Gadara、Dilip Kumar Singh、Sandhya Subash、Guihua Yue、Deepak Suresh Ahire、Chris Bohl、Maciej Czerwiński、Stephanie Helmstetter、Scott A. Heyward、Robert S. Jones、Cyrus Khojasteh、Ryota Kikuchi、Priyanka Kulkarni、Bin Ma、Bernard P. Murray、Chris Seib、Bill J. Smith、David M. Stresser、Mitchell E. Taub、Ting Wang
单位：Cincinnati Children's Hospital Medical Center；Washington State University Spokane；Gilead Sciences (United States)；BioIVT (United States)；Genentech；AbbVie (United States)；Takeda (United States)；Terminal Phase Consulting LLC Colorado Springs CO USA
摘要
Clinical Pharmacology & Therapeutics 2026年11月刊发表综述，系统表征溶酶体水解酶和转运体的功能特征及其随年龄的变化规律，探讨这些内源性因素对小分子药物和生物制剂代谢与转运的影响，为老年及儿科患者个体化给药提供理论基础。
AI 主编 · 推荐理由推荐理由
溶酶体通路是近年被重新认识的 drug metabolism 途径，尤其影响抗体药物和肽类药物的体内处置。本文对从业者调整特殊人群剂量设计、解读临床PK数据具有直接参考价值。