曲马多与羟考酮或氢可酮合用增加阿片类药物负担但不改善术后疼痛控制
Tramadol Co‐Administration with Oxycodone or Hydrocodone Increases Opioid Burden without Improving Postoperative Pain Control
作者：Noor A. Nahid、Ahmed I. Soliman、Jordan F. Baye、Natasha J. Petry、Chancellor F. Gray、Rachel A. Myers、Erica N. Elwood、Elizabeth C. Harris、Hrishikesh Chakraborty、Simona Volpi、Renee Rider、Paul R. Dexter、Josh F. Peterson、Todd C. Skaar、Hari K. Parvataneni、Larisa H. Cavallari、Julie A. Johnson
单位：Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.；Department of Pharmacy Practice and Science, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.；Department of Pharmacy Practice, South Dakota State University, Brookings, South Dakota, USA.；Sanford Health Imagenetics, Sioux Falls, South Dakota, USA.；Department of Pharmacy Practice, School of Pharmacy, North Dakota State University, Fargo, North Dakota, USA.；Florida Orthopaedic Institute, Gainesville, Florida, USA.；Clinical Research Unit, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.；Center of Pharmacogenomic and Precision Medicine, University of Florida, College of Pharmacy, Gainesville, Florida, USA.
摘要
2026年8月17日发表于《临床药理学与治疗学》的一项研究显示，曲马多与羟考酮或氢可酮联合给药会增加阿片类药物总体暴露量，但并未改善术后疼痛控制。研究提示该联合方案可能增加不良反应风险而无额外获益，对临床合理用药及药物警戒具有参考价值。
AI 主编 · 推荐理由推荐理由
该研究提示联合阿片类药物存在安全性风险，建议药企药物警戒部门评估相关产品的联合用药信号，必要时更新说明书中的相互作用与风险提示，临床研发中避免不必要的联合用药。