卒中后出院老年患者抗癫痫药物使用与生存结局研究
Post‐Discharge Antiseizure Medication Use and Poststroke Survival: An Emulated Target Trial in Older Adults
作者：Madhav Sankaranarayanan、Maria A. Donahue、Julianne D. Brooks、Shuo Sun、Joseph P. Newhouse、Deborah Blacker、Sebastien Haneuse、Sonia Hernández Díaz、Lidia M. V. R. Moura
单位：Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.；Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.；Department of Population Health Sciences, Weill Cornell Medicine, New York, New York, USA.；Center for Global Health and Mongan Institute, Massachusetts General Hospital, Boston, Massachusetts, USA.；Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA.；Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.；Harvard Kennedy School, Cambridge, Massachusetts, USA.；Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
摘要
发布于2026年10月《药物流行病学与药物安全》期刊。该研究采用目标试验模拟方法，分析卒中后出院老年患者使用抗癫痫药物的生存率影响，为临床用药决策提供真实世界证据参考。
AI 主编 · 推荐理由推荐理由
研究揭示了卒中后抗癫痫药物使用的获益-风险轮廓，药企PV部门可借此评估现有产品的安全信号，临床研究者参与相关试验时亦可参考其模拟目标试验设计方法。