母体安乃近暴露与重大先天畸形及围产期不良结局风险：基于人群的队列研究
Maternal Dipyrone Exposure and Risk of Major Congenital Malformations, Adverse Perinatal and Postnatal Outcomes: A Population‐Based Cohort Study
作者：Itamar Ben Shitrit、Daphna Idan、Ariel Avraham Hasidim、Tal Michael、Amalia Levy、Gali Pariente、Eitan Lunenfeld、Sharon Daniel
单位：Department of Epidemiology, Biostatistics, and Community Health Sciences, School of Public Health, Faculty of Health Sciences, University of the Negev, Beer-Sheva, Israel.；Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.；Clinical Research Center, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.；Department of Pediatrics A, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.；Gray Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.；Department of Obstetrics and Gynecology, Faculty of Health Sciences Ben-Gurion University of the Negev and Soroka University Medical Center, Beer-Sheva, Israel.；Adelson School of Medicine, Ariel University, Ariel, Israel.；Department of Pediatrics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
摘要
2026年8月7日，《临床药理学与治疗学》在线发表一项基于人群的队列研究，评估孕期母体使用安乃近（dipyrone）与重大先天畸形、围产期及产后不良结局的关联。研究覆盖大规模人群，比较暴露组与未暴露组，分析风险比。结果提示安乃近暴露可能增加特定畸形风险，但需进一步验证。该研究为孕期用药安全提供重要证据。
AI 主编 · 推荐理由推荐理由
安乃近在部分国家仍广泛使用，孕期用药安全性存疑。该研究结果可能影响监管决策和临床指南，注册与医学事务部门应关注并评估对产品说明书及风险管理计划的影响。